Identification of genetic networks.
نویسندگان
چکیده
In this report, we propose the use of structural equations as a tool for identifying and modeling genetic networks and genetic algorithms for searching the most likely genetic networks that best fit the data. After genetic networks are identified, it is fundamental to identify those networks influencing cell phenotypes. To accomplish this task we extend the concept of differential expression of the genes, widely used in gene expression data analysis, to genetic networks. We propose a definition for the differential expression of a genetic network and use the generalized T2 statistic to measure the ability of genetic networks to distinguish different phenotypes. However, describing the differential expression of genetic networks is not enough for understanding biological systems because differences in the expression of genetic networks do not directly reflect regulatory strength between gene activities. Therefore, in this report we also introduce the concept of differentially regulated genetic networks, which has the potential to assess changes of gene regulation in response to perturbation in the environment and may provide new insights into the mechanism of diseases and biological processes. We propose five novel statistics to measure the differences in regulation of genetic networks. To illustrate the concepts and methods for reconstruction of genetic networks and identification of association of genetic networks with function, we applied the proposed models and algorithms to three data sets.
منابع مشابه
Modeling gene regulatory networks: Classical models, optimal perturbation for identification of network
Deep understanding of molecular biology has allowed emergence of new technologies like DNA decryption. On the other hand, advancements of molecular biology have made manipulation of genetic systems simpler than ever; this promises extraordinary progress in biological, medical and biotechnological applications. This is not an unrealistic goal since genes which are regulated by gene regulatory ...
متن کاملProject Portfolio Risk Response Selection Using Bayesian Belief Networks
Risk identification, impact assessment, and response planning constitute three building blocks of project risk management. Correspondingly, three types of interactions could be envisioned between risks, between impacts of several risks on a portfolio component, and between several responses. While the interdependency of risks is a well-recognized issue, the other two types of interactions remai...
متن کاملComparison of Hubs in Effective Normal and Tumor Protein Interaction Networks
ABSTRACTIntroduction: Cancer is caused by genetic abnormalities, such as mutation of ontogenesis or tumor suppressor genes which alter downstream signaling pathways and protein-protein interactions. Comparison of protein interactions in cancerous and normal cells can be of help in mechanisms of disease diagnoses and treatments. Methods: We constructed protein interaction networks of cancerous a...
متن کاملGMDH Type Neural Networks and Their Application to the Identification of the Inverse Kinematics Equations of Robotic Manipulators (RESEARCH NOTE)
متن کامل
Intrusion Detection in Wireless Sensor Networks using Genetic Algorithm
Wireless sensor networks, due to the characteristics of sensors such as wireless communication channels, the lack of infrastructure and targeted threats, are very vulnerable to the various attacks. Routing attacks on the networks, where a malicious node from sending data to the base station is perceived. In this article, a method that can be used to transfer the data securely to prevent attacks...
متن کاملIdentification of effect of social networks on the behavior of the students (Case Study: Azad University of Kashan
In this paper, we try to see how virtual networks can af- fect the behavior of the young. Since there are so many indices to be affected by social networks, we evaluate these effects only on 10 more comprehensive behaviors as follows: identity, getting information and the rumors, rationalism,life style, spare time, religions rituals and cer- emonies, interaction with family, employment and eco-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Genetics
دوره 166 2 شماره
صفحات -
تاریخ انتشار 2004